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I think the virus could have absolutely escaped from a lab with shit handling procedures or into animals in close proximity to humans from a lab. Designed? I doubt it, the pharma companies don't need the extra revenue, that doesn't mean they won't take it though...obviously. And it also doesn't mean that the world isn't going through a more "natural" extinction cycle, just is totally possible humans are more culpable.

And also, researchers would likely be able to tell if it had engineering hallmarks and at least a decent sized group would be out there saying shit or getting murdered before they could.